Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cells.

ABSTRACT:

Background

While primary breast cancer (BC) is often effectively managed, metastasis remains the primary cause of BC-related fatalities. Gaps remain in our understanding of the mechanisms regulating cancer cell organotropism with predilection to specific organs. Unraveling mediators of site-specific metastasis could enhance early detection and enable more tailored interventions. Liquid biopsy represents an innovative approach in cancer involving the analysis of biological materials such as circulating tumor DNA and tumor-derived extracellular vesicles (EV) found in body fluids like blood or urine. This offers valuable insights for characterizing and monitoring tumor genomes to advance personalized medicine in metastatic cancers.

Methods

We performed in-depth analyses of EV c

SUBMITTER: Nadeau A 

PROVIDER: S-EPMC12100931 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature