Regulation of placental development and function by ubiquitination.

ABSTRACT: The proper distribution of nutrients and metabolites between the mother and fetus is one important factor for successful pregnancy. As a bridge, the placenta plays a key role in sensing the nutritional needs of the fetus, coordinating the maternal nutrition supply, and enhancing its nutritional transport capabilities. Imperfect placental development can lead to pregnancy-related disorders such as preeclampsia, recurrent miscarriage, and/or fetal growth restriction, posing risks to both mother and child in the short and long term. However, current understanding of the human placenta remains as a "black box", and its developmental control mechanisms for adaptive pregnant regulation still needs to be elucidated. As one form of post-translational modification (PTM), ubiquitination plays an imp

SUBMITTER: Wang X 

PROVIDER: S-EPMC12101010 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature