FAM111B and FANCD2, a dual expression signature, defines a distinct phenotype of pancreatic cancer.

ABSTRACT:

Background

Despite various treatment strategies, the incidence and mortality of pancreatic cancer (PC) are among the highest for malignant tumors. Furthermore, there is a lack of effective molecular typing and targeted therapy to treat PC subtypes.

Methods

Multiplex immunofluorescence experiments were performed to explore the roles of FAM111B, FANCD2, KRAS and TP53 in human PC tissues. Kaplan-Meier survival curves were generated and a nomogram was prepared for prognostic prediction. Protein correlations were analyzed using human PC tissues and TCGA and GEO data. Pathways analysis, immunoanalysis, and drug susceptibility analysis were performed based on information in the TCGA database.

Results

Our results indicate that expression of FAM111B and FANCD2 is correlated in

SUBMITTER: Wei F 

PROVIDER: S-EPMC12101032 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature