Matrine Inhibits the Wnt3a/β-Catenin Signalling to Attenuate Pressure Overload-Induced Atrial Remodelling and Vulnerability to Atrial Fibrillation.

ABSTRACT: Atrial fibrillation (AF) is closely associated with atrial electrical and structural remodelling, yet effective drug strategies remain limited. Matrine (MAT), the active compound in Sophora flavescens, has shown anti-AF effects, but its mechanisms are unclear. This study explored MAT's impact on pressure overload-induced AF using clinical samples, bioinformatics, network pharmacology and murine models, focusing on the canonical Wnt signalling. A murine pressure overload model was established via transverse aortic constriction (TAC) surgery for 4 weeks. Programmed electrical stimulation, langendorff perfusion, echocardiography, Masson's trichrome staining and western blotting were used to evaluate the potential effects and mechanisms of MAT. The results demonstrated that TAC-induced atrial

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12101071 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature