<i>COMT</i> Genetic Variants and BDNF Level Associations with Cannabinoid Plasma Exposure: A Preliminary Study.

ABSTRACT: Cannabis sativa L. shows potent anti-inflammatory activity, resulting in an interesting pharmacological option for pain management. The aim of the study was to evaluate the association between pharmacogenetics, neurological and inflammatory biomarkers, and cannabinoid plasma exposure in patients treated with cannabis. A total of 58 patients with a diagnosis of neuropathic and chronic pain treated with medical cannabis were analyzed. Cannabis was administered as a decoction (n = 47) and as inhaled cannabis (n = 11): 30 patients were treated with cannabis with high THC, while 28 patients were treated with cannabis with reduced THC (plus CBD). Cannabinoid plasma concentrations were obtained with UHPLC-MS/MS. Allelic discrimination was assessed by real-time PCR. Inflammation biomarkers

SUBMITTER: Manca A 

PROVIDER: S-EPMC12101174 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature