Genetic evolution and alterations in pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus.

ABSTRACT: Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) and HP-PRRSV variant strains remain prevalent in China and Southeast Asian countries. However, their epidemiological aspects, genomic characteristics, relationships with vaccine strains, and changes in pathogenicity remain unclear. In this study, 2509 global L8.7 ORF5 sequences were utilized for analysis, we classified L8.7 into 7 groups (L8.7.1-L8.7.7). L8.7.1-L8.7.3 strains corresponded to previously reported classical PRRSVs, intermediate strains, and HP-PRRSVs, respectively, whereas L8.7.4-L8.7.7 were designated HP-like PRRSVs. Statistical analysis revealed that HP-like PRRSVs were the most prevalent among L8.7 strains, and L8.7.5 and L8.7.6 strains accounted for the highest proportions in recent years. A

SUBMITTER: Li C 

PROVIDER: S-EPMC12101601 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature