Association between aspartate aminotransferase to alanine aminotransferase ratio and 28-day mortality of ICU patients: A retrospective cohort study from MIMIC-IV database.

ABSTRACT:

Background

Prior studies have linked the aspartate aminotransferase to alanine aminotransferase ratio (AAR) with negative health outcomes in the elderly and specific populations. However, the impact of AAR on the prognosis of the entire population in the intensive care unit (ICU) remains unclear. This study aimed to determine the correlation between AAR and the mortality among adult ICU patients.

Method

Patient data were retrieved from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and stratified into quartiles by AAR. Survival analysis using the Kaplan-Meier curves was conducted to compare survival across quartiles. The primary outcome was 28-day mortality, with secondary outcomes including 60-day, 90-day, and 365-day mortality, along with ICU-free,

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12101646 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature