Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria.

ABSTRACT: Contaminated household water in peri-urban communities is a reservoir for virulent Escherichia coli, but its role in the environmental transmission of antibiotic resistance genes (ARGs) remains poorly understood. This study characterized E. coli from household water and additionally aimed to investigate the transmissibility of ARGs from drug-resistant isolates. Twenty-five E. coli isolates from thirteen household well water sources were tested for resistance to 14 antibiotics by disc diffusion and whole-genome sequenced using the Illumina platform. The ARGs and plasmid replicon types were respectively predicted using ResFinder and PlasmidFinder. Multidrug-resistant strains carrying plasmid replicons found in unrelated strains were conjugated with nalidixic acid-resistant (NALR) E. coli C60

SUBMITTER: Rabiu AG 

PROVIDER: S-EPMC12101698 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature