Pupil responses to melanopsin-isolating stimuli as a potential diagnostic biomarker for glaucoma.

ABSTRACT:

Purpose

To test whether differences in pupil responses to melanopsin-isolating spectral stimuli in glaucoma may be useful as a diagnostic biomarker.

Methods

Spectral stimuli were presented to 20 glaucoma and 15 age-similar healthy control participants. Stimuli were pairs of silent-substitution spectra designed to provide (1) equal stimulation to cone photoreceptors but maximum (~325%) contrast to melanopsin or (2) equal stimulation to melanopsin but ~325% contrast to cones. Narrowband long-wavelength/red (657 nm) and short-wavelength/blue (471 nm) pulses were also presented from a dark background to 16 glaucoma and 12 control participants. Pulses lasted 3 seconds and pupil size was measured for 15 seconds. Pupil response metrics were compared by t-test and relationships with

SUBMITTER: Denniss J 

PROVIDER: S-EPMC12101769 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature