Bioinformatics and system biology approach to discover the common pathogenetic processes between COVID-19 and chronic hepatitis B.

ABSTRACT:

Introduction

The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents a significant global public health threat. Concurrently, hepatitis B virus (HBV) remains a significant public health challenge. While previous studies have indicated an association between COVID-19 and chronic hepatitis B, the common underlying pathogenesis of these diseases remains incompletely understood.

Methods

To investigate the shared molecular mechanisms between chronic HBV infection and COVID-19, a comprehensive investigation was conducted using bioinformatics and systems biology. Specifically, we utilized RNA-seq datasets (GSE196822 and GSE83148) to identify differentially expressed genes (DEGs) associated with b

SUBMITTER: Ma X 

PROVIDER: S-EPMC12101853 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature