The performance of plasma p-tau217 in Black middle-aged and older adults.

ABSTRACT:

Introduction

Medical conditions prevalent in Black adults within the United States have been associated with plasma tau phosphorylated at threonine 217 (p-tau217); however, insufficient p-tau217 research has been conducted with Black adults.

Methods

Participants included n = 233 predominantly cognitively unimpaired adults enrolled in the African Americans Fighting Alzheimer's in Midlife study. Subsamples had creatinine (n = 137) and positron emission tomography (PET; amyloid-PET = 65 [amyloid-PET-positive = 16/65]; tau-PET = 70). We tested whether p-tau217 (ALZPath, Inc.) varied by medical condition and amyloid- and tau-PET-positivity status and assessed the diagnostic accuracy of p-tau217.

Results

Estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m²

SUBMITTER: Ennis GE 

PROVIDER: S-EPMC12101965 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature