Molecular subtype characteristics and development of prognostic model based on inflammation-related gene in lung adenocarcinoma.

ABSTRACT: As one of the leading causes of death worldwide, lung adenocarcinoma (LUAD) currently lacks satisfactory treatment outcomes. The inflammatory process, closely associated with the formation of the tumor microenvironment and immune evasion, plays a crucial role in LUAD development. This study utilized data from public databases to analyze inflammation-related genes (INF) associated with prognosis in LUAD. Based on differentially expressed INF, molecular subtypes of LUAD were identified. Subsequently, a novel INF scoring system was developed to establish a prognostic model for LUAD patients, assessing its independence and reliability. Comprehensive evaluations, including immune microenvironment infiltration features, somatic mutation characteristics, and differences in immune therapy responsi

SUBMITTER: Hu X 

PROVIDER: S-EPMC12102027 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature