New information triggers prospective codes to adapt for flexible navigation.

ABSTRACT: Navigating a dynamic world requires rapidly updating choices by integrating past experiences with new information. In hippocampus and prefrontal cortex, neural activity representing future goals is theorized to support navigational planning. However, it remains unknown how prospective goal representations incorporate new, pivotal information. Accordingly, we designed a navigation task that precisely introduces new information using virtual reality, and we recorded neural activity as male mice flexibly adapted their planned destinations. Here we show that new information triggered increased hippocampal prospective representations of both possible goals; while in prefrontal cortex, new information caused prospective representations of choices to rapidly shift to the new choice. When mice did

SUBMITTER: Prince SM 

PROVIDER: S-EPMC12102184 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature