The impact of lipidome on intervertebral disk degeneration, low back pain, and sciatica: a Mendelian randomization study.

ABSTRACT: Degeneration of intervertebral discs is a significant factor in chronic lower back pain, impacting millions annually. Existing studies propose a potential link between lipids and disc disease, though causal relationships remain unclear. The objective of this study is to explore the causal connections between lipids, lower back pain, disc degeneration, and the risk of sciatica In this research, we utilized a comprehensive GWAS dataset encompassing 179 lipid traits to explore the causal connections between lipids and the susceptibility to conditions such as lower back pain (LBP), intervertebral disc degeneration (IVDD), and sciatica. To establish causality, we employed two-sample Mendelian randomization, supplemented by Bayesian model averaging for verification. Our assessment of diversity a

SUBMITTER: Pang ZY 

PROVIDER: S-EPMC12102376 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature