Exploring the genetic causal inference between plasma lipidome and lung carcinoma: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Clinical observational studies have highlighted differences in plasma lipid profiles between lung carcinoma patients and healthy individuals. However, the causal relationship underlying these differences remains unclear. This study aims to investigate the bidirectional causal relationship between 179 plasma lipids and lung carcinoma.

Methods

A bivariate two-sample Mendelian randomization (MR) study was conducted using data from public genome-wide association studies (GWAS). The primary analytical technique employed was the inverse variance weighting method (IVW), with MR-Egger, weighted-median, and weighted mode as supplementary methods. Sensitivity analyses including Cochran's Q test and MR-Egger intercept test were performed to ensure the robustness of the resul

SUBMITTER: Pan H 

PROVIDER: S-EPMC12102421 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature