Molecular networking reveals indole diterpenoids from the marine-derived fungus <i>Penicillium</i> sp. N4-3.

ABSTRACT: MS/MS-based molecular networking is an effective strategy to rapidly dereplicate known compounds and to guide the discovery process for new and novel natural products. In the present study, the chemical diversity of indole diterpenoids from the marine-derived fungus Penicillium sp. N4-3 was investigated using molecular networking techniques. Guided by this information, targeted isolation resulted in two new indole diterpenoids shearinines R and S (1, 2) and an oxidative artifact shearinine T (3), together with the verification of two known analogs (4, 5). Furthermore, five indole diterpenoids (6-10), including three putatively new ones, shearinines U-W (6, 9, 10), were predicted from the molecular ion cluster by t

SUBMITTER: Chen M 

PROVIDER: S-EPMC12102448 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature