Exploring the Healing Potential of Aqueous Extract of <i>Baccaurea ramiflora</i> Leaves in Inflammation: A Cytokine and Prostaglandin Modulator.

ABSTRACT: Baccaurea ramiflora is a common edible nutritious plant that has been associated with a variety of medicinal attributes. This study investigated the anti-inflammatory effects of the aqueous extract of B. ramiflora leaves (BrLAE) in a complete Freund's adjuvant (CFA) induced inflammatory model. BrLAE was prepared by the cold maceration process and screened for phytochemical and antioxidant analyses. Inflammation was induced by a single intra-planter (i.pl.) injection of CFA (100 μL) in the hind paws of male Wistar rats. After 7 days of immunization, paw edema was measured weekly (Day 7-Day 35) by digital plethysmometer and vernier caliper. Animals were daily treated with either methotrexate (MTX) or BrLAE (300, 600, and 1000 mg/kg) from Day 7 to Day 35. At the end of the exper

SUBMITTER: Malik MNH 

PROVIDER: S-EPMC12102493 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature