The type IV secretion system of <i>Patescibacteria</i> is homologous to the bacterial monoderm conjugation machinery.

ABSTRACT: The Candidate Phyla Radiation, also known as Patescibacteria, represents a vast and diverse division of bacteria that has come to light via culture-independent 'omics' technologies. Their limited biosynthetic capacity, along with evidence of their growth as obligate epibionts on other bacteria, suggests a broad reliance on host organisms for their survival. Nevertheless, our understanding of the molecular mechanisms governing their metabolism and lifestyle remains limited. The type IV secretion system (T4SS) represents a superfamily of translocation systems with a wide range of functional roles. T4SS genes have been identified in the Patescibacteria class Saccharimonadia as essential for their epibiotic growth. In this study, we used a comprehensive bioinformatics appr

SUBMITTER: Quinonero-Coronel MDM 

PROVIDER: S-EPMC12102498 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature