Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA.

ABSTRACT: Diabetic nephropathy, a serious diabetes complication, lacks effective treatments. Traditional Chinese medicine Zuogui Pill (ZGP) and Yougui Pill (YGP) have a definite clinical adjunctive effect on diabetic nephropathy. Given their similar compositions, studying their shared mechanisms could provide novel perspectives into discovering therapeutic targets for diabetic nephropathy. Extraction of ZGP (EZP) and YGP (EYP) was prepared by in vitro digestion. EZP and EYP inhibited the gene expression of FN1 and MMP9 in a renal fibrosis cell model. A transcriptional regulatory network revealed EZP and EYP have similar mechanisms, with HIF1A as a key transcription factor. In an insulin resistance cell model, EZP and EYP led to the decrease in glucose consumption. A transcriptional reg

SUBMITTER: Qiao L 

PROVIDER: S-EPMC12102528 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature