Mammary leukocytes function of endotoxin tolerant goat induced by intrauterine infusion of lipopolysaccharide.

ABSTRACT: A previous study found that repeated intrauterine infusions of lipopolysaccharide (LPS) followed by an LPS infusion into the mammary glands attenuated the mammary inflammatory response. This suggests that repeated LPS infusion into the uterus promotes endotoxin tolerance (ET) in the mammary gland. However, the specific changes in mammary glands under ET conditions remain unclear. We hypothesized that ET affects leukocyte function in milk. This study aimed to investigate leukocyte function in milk under ET conditions induced through repeated LPS infusions into the uterus for three days followed by LPS infusion into the mammary glands of goats. Goats in the IU group (n = 17) received an infusion of 100 μg LPS in 5 ml saline into the uterus for three consecutive days (d -3, -2, and -1), where

SUBMITTER: Jaisue J 

PROVIDER: S-EPMC12102568 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature