PUF60-Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration.

ABSTRACT:

Background

As an essential transcription factor, Myc-associated zinc-finger protein (MAZ) is frequently upregulated in many human tumors and is a well-documented oncogene. However, we found high expression of MAZ was closely associated with good survival outcomes in patients with stomach adenocarcinoma (STAD), and the underlying mechanism involved remains to be elucidated. We hypothesize that alternative splicing of MAZ plays an important role.

Methods

Pan-cancer analysis of MAZ expression and prognostic significance was performed using The Cancer Genome Atlas (TCGA) data, with emphasis on its divergent prognostic impact in gastric cancer (GC). MAZ protein levels were further validated in 356 GC tissue samples via immunohistochemistry. Functional investigations encompassed M

SUBMITTER: Xing D 

PROVIDER: S-EPMC12102611 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature