Antiatherogenic and plaque stabilizing effects of saffron ethanolic extract in atherosclerotic rabbits.

ABSTRACT:

Background

Saffron, the dried stigma of the flower Crocus sativus L., has been shown to have therapeutic effects on cardiovascular diseases. Several studies have explored the impact of saffron on atherosclerosis. However, the mechanism underlying the plaque-stabilizing and antiatherosclerotic effects of saffron has not been widely studied. Therefore, this study aimed to investigate the mechanism of the antiatherosclerotic and plaque-stabilizing effects of saffron ethanolic extract in experimentally induced atherosclerotic rabbits.

Methods

New Zealand White rabbits were fed a 1% high-cholesterol diet (HCD) for 8 weeks to induce established atherosclerosis. The rabbits were then treated with 50 or 100 mg/kg/day saffron ethanolic extract (SAF), simvastatin (2.5 mg/kg/day) or pl

SUBMITTER: Rahim INA 

PROVIDER: S-EPMC12102833 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature