Cross-species transcriptome-wide meta-analysis of anterior cruciate ligament rupture.

ABSTRACT:

Background

The Anterior Cruciate Ligament (ACL) plays a critical role in maintaining the musculoskeletal stability of the knee. Its injury has been linked to an increased risk of developing osteoarthritis. This study aims to identify cross-species responses to ACL rupture providing insights on its molecular basis. We analyzed five publicly available transcriptomic datasets from Homo sapiens, Mus musculus, Canis lupus familiaris, and Oryctolagus cuniculus. Differential gene expression analysis was performed for each dataset, producing a genome-wide transcriptional signature of fold-change significance for individual genes. Stouffer's method was used to integrate the results, identifying genes significantly deregulated across all species. Additionally, gene-set enrichment analysis re

SUBMITTER: Beccacece L 

PROVIDER: S-EPMC12102845 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature