Association of the single-nucleotide polymorphism in the MFG-E8 gene with coronary heart disease in Chinese Han population.

ABSTRACT: Coronary atherosclerosis narrows or occludes blood vessels, resulting in myocardial ischemia and hypoxia, which ultimately leads to coronary heart disease (CHD). The pathogenesis of CHD remains insufficiently elucidated. A widely accepted hypothesis is that various stimuli induce arterial intima injury, and atherosclerosis (AS)formation reflects the inflammatory-fibroproliferative response of the intima to such injury. Milk fat globule epidermal growth factor 8 (MFG-E8) is expressed in cells implicated in CHD development, including macrophages, endothelial cells, and vascular smooth muscle cells, suggestion it play a regulatory role in multiple key stages of AS progression (such as foam cell formation and plaque instability). However, theassociation between MFG-E8 gene polymorphisms and CH

SUBMITTER: Wang D 

PROVIDER: S-EPMC12102855 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature