Resolving native GABA_A receptor structures from the human brain.

ABSTRACT: Type A GABA (γ-aminobutyric acid) receptors (GABA_A receptors) mediate most fast inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety, depression and insomnia and for anaesthetics^1,2. These receptors comprise a complex array of 19 related subunits, which form pentameric ligand-gated ion channels. The composition and structure of native GABA_A receptors in the human brain have been inferred from subunit localization in tissue^1,3, functional measurements and structural analysis from recombinant expression^4-7 and in mice⁸. However, the arrangements of subunits that co-assemble physiologically in native human GABA_A receptors remain unknown. Here we isolated α1 subunit-containing GABA

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12103249 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature