Bridging Genomic Research Disparities in Osteoporosis GWAS: Insights for Diverse Populations.

ABSTRACT:

Purpose of review

Genome-wide association studies (GWAS) have significantly advanced osteoporosis research by identifying genetic loci associated with bone mineral density (BMD) and fracture risk. However, disparities persist due to the underrepresentation of non-European populations, limiting the applicability of polygenic risk scores (PRS). This review examines recent advancements in osteoporosis genetics, highlights existing disparities, and explores strategies for more inclusive research.

Recent findings

European-focused GWAS have identified key loci for osteoporosis, including WNT signaling (SOST, LRP5) and RUNX2 transcriptional regulation. However, fewer than 40% of these variants can be replicated in Asian and African populations. Emerging studies in non-European grou

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12103327 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature