Potential associations between gut and skin microbiota and lung cancer: a bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Recent research has demonstrated that microbes have a vital impact on cancer by governing immune responses, managing inflammation, and employing other methods. However, the specific relationship between the microbiome and lung cancer requires further investigation to be fully understood.

Methods

Summary data regarding lung cancer outcomes and skin bacteria were sourced from the GWAS and GWAS catalog databases, respectively. Data on gut microbiota were acquired from the MiBioGen database. Using these datasets, we performed Mendelian randomization (MR) and linkage disequilibrium score regression (LDSC) analysis to evaluate the genetic relationships and possible relationships between gut and skin microbiota and lung cancer.

Results

The LDSC analysis indicated

SUBMITTER: Guo Z 

PROVIDER: S-EPMC12103405 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature