Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets.

ABSTRACT:

Objective

While testicular cancer is highly curable, drug resistance remains a challenge in relapsed or refractory cases. This study explores the immune system's role in resistance mechanisms via bidirectional Mendelian Randomization (MR) analysis of 731 immune cell phenotypes.

Method

We conducted a two-sample bidirectional MR analysis using IVW, MR-Egger, weighted median, and other models, leveraging public genetic datasets. Sensitivity analyses were performed to ensure robustness and assess pleiotropy.

Results

The MR analysis revealed 12 immune cell phenotypes causally linked to testicular cancer development and 16 phenotypes significantly modulated by the disease, highlighting potential therapeutic resistance mechanisms. Several identified immune markers were assoc

SUBMITTER: Xiao L 

PROVIDER: S-EPMC12103431 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature