Prognostic and therapeutic insights from lactate metabolism and tumor immune microenvironment in head and neck squamous cell carcinoma.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) exhibits a poor prognosis, particularly in advanced stages characterized by high recurrence and metastasis rates. This study investigates the role of lactate metabolism in HNSCC, aiming to develop a prognostic model to predict immunotherapy outcomes. Genomic and clinical data from The Cancer Genome Atlas and Gene Expression Omnibus databases were analyzed, focusing on 233 lactate metabolism-related genes (LMGs). Differential expression and Cox regression analyses identified two significant prognostic genes: glycogen phosphorylase L (PYGL) and solute carrier family 16 member 3 (SLC16 A3, encoding MCT4). A lactate risk score (LRS) model constructed from these genes demonstrated robust predictive accuracy across multiple validation datasets. Multi

SUBMITTER: Jiang H 

PROVIDER: S-EPMC12103450 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature