ZeXieYin formula alleviates atherosclerosis by regulating SBAs levels through the FXR/FGF15 pathway and restoring intestinal barrier integrity.

ABSTRACT:

Background

Atherosclerosis (AS) is the most common cardiovascular disease (CVD), despite an overall declining incidence, AS remains a leading cause of death worldwide. The ZeXieYin formula (ZXYF), one of the thirteen formulas recorded in HuangDiNeiJin, a classical book of Traditional Chinese Medicine (TCM), has previously demonstrated efficacy in reducing blood lipids and combating AS. However, the precise mechanism by which it regulates blood lipids remains unclear. Given the close correlation between bile acid metabolism and cholesterol metabolism, it is imperative to elucidate the intrinsic mechanisms through which ZXYF treats AS.

Purpose of the research

This study aims to investigate the pivotal role of enterohepatic bile acid circulation in enhancing intestinal barrier

SUBMITTER: Zhou S 

PROVIDER: S-EPMC12103746 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature