Bioinformatics and experimental validation of ferroptosis-related genes in steroid-induced osteonecrosis of the femoral head.

ABSTRACT:

Background

Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive condition that causes increasing disability. It is thought to result from reduced blood flow and oxygen levels in the femoral head, with reactive oxygen species (ROS) playing a key role in triggering ferroptosis. However, the role of ferroptosis in SONFH progression remains underexplored. This study aimed to identify and validate key genes associated with ferroptosis in SONFH using bioinformatics.

Methods

The study analyzed the SONFH dataset GSE123568, which includes data from 30 SONFH patients and 10 controls. Weighted gene co-expression network analysis (WGCNA) was used to identify differentially expressed genes (DEGs) between the SONFH and control groups. Core genes were identified by in

SUBMITTER: Guo MG 

PROVIDER: S-EPMC12104091 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature