Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study.

ABSTRACT:

Background

To investigate whether differences between motoric cognitive risk syndrome (MCRS) and mild cognitive impairment (MCI) are of vascular origin, we compared the risk of incident cardiovascular disease in both groups in a population-based study.

Methods

We included 2710 dementia-free participants of the Rotterdam Study who underwent structured interviews, as well as gait and cognitive assessments. MCRS was defined as subjective cognitive complaints in combination with slow gait speed. MCI was defined as subjective cognitive complaints and objective impairment in one cognitive domain. We used Cox proportional hazards models adjusted for age, sex, and cardiovascular risk factors to obtain hazard ratios (HR) for the composite outcome of cardiovascular disease, including

SUBMITTER: Menart AC 

PROVIDER: S-EPMC12104810 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature