Risk factors for neuroendocrine neoplasms: protocol for a case-control study based on a record linkage of registry and claims data.

ABSTRACT:

Background

Recent studies showed an increase in neuroendocrine neoplasms, especially for the digestive tract. Several risk factors have been suggested to explain this increase, including a family history of cancer, tobacco smoking, alcohol consumption and metabolic disorders such as diabetes and obesity. Another risk factor may be depressive disorders, which could increase the risk of neuroendocrine neoplasms either directly or mediated through associated risk behaviours and/or antidepressant medication. Here, we outline the design of our study to identify the risk factors for neuroendocrine neoplasms in Germany.

Methods and analysis

A case-control study of the resident population of Bavaria, the second most populous federal state in Germany, based on a record linkage of dat

SUBMITTER: Voigtlander S 

PROVIDER: S-EPMC12104912 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature