Preoperative partial breast radiation for favorable early-stage breast cancer: a narrative review.

ABSTRACT:

Background and objective

Adjuvant partial breast irradiation (PBI) is a well-established treatment for appropriately selected women with early-stage breast cancer. Preoperative PBI is a newer approach with some advantages compared to post-operative PBI, including potential for decreased toxicity, tumor response assessment, treatment stratification, and prognostication. Here, we summarize emerging data from prospective studies demonstrating safety and efficacy of preoperative PBI and explore techniques for assessing tumor response. We further review ongoing studies and discuss the intriguing possibility of utilizing this technique to adopt a non-operative approach for select patients with early-stage breast cancer.

Methods

We conducted a comprehensive literature search utiliz

SUBMITTER: McDuff SGR 

PROVIDER: S-EPMC12104959 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature