De-escalation of axillary interventions in the management of breast cancer patients following neoadjuvant systemic treatment.

ABSTRACT: The role of axillary surgery in the management of breast cancer continues to evolve as our understanding of breast cancer biology improves, coupled with an increasing availability and efficacy of systemic therapy options. In the current context, the main goal of axillary surgery is staging. In this review, we discuss the role of axillary surgery in patients receiving neoadjuvant systemic therapy and appraise the current state of de-escalation of axillary interventions. We argue that accuracy of limited axillary staging procedure is important, not so much from axillary control point of view but from the systemic undertreatment point of view. We suggest that comparative evaluation of different limited axillary staging procedures from oncological safety perspective should therefore not be bas

SUBMITTER: Tondare A 

PROVIDER: S-EPMC12104960 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature