Identification of Gut Biomarkers of FPIES in a Longitudinal Comparative Pediatric Study.

ABSTRACT:

Background

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated allergy without known biomarkers. We aimed to compare fecal biomarkers related to gut inflammation and immunity in children with FPIES, with resolved FPIES (tolerant), and in matched controls.

Methods

Stools were collected from FPIES children on elimination diet, before and after an oral food challenge (OFC) performed to assess their natural tolerance, at the end of a follow-up in tolerant FPIES children, and in matched controls (1:1 ratio). Concentrations of calprotectin, EDN (eosinophilic derived neurotoxin), and secretory IgA (sIgA) underwent comparative paired analysis.

Results

Thirty-eight patients were included (age: 1.3 years old, interquartile range: IQR [0.9-2.0]), of which 2

SUBMITTER: Lemoine A 

PROVIDER: S-EPMC12105057 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature