The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis.

ABSTRACT:

Background

Asthma is a common chronic respiratory disease, and its potential association with the central nervous system has garnered increasing attention in recent years. While observational studies suggest that asthma may affect hippocampal structure and function through mechanisms such as chronic inflammation and hypoxia, its causal relationship remains unclear.

Methods

In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing large-scale genome-wide association study (GWAS) data to systematically investigate the potential causal relationship between asthma and hippocampal volume. Data from a GWAS of asthma involving 155,386 individuals of European ancestry and GWAS imaging-derived phenotypes (IDPs) of hippocampal volume from 33,219 European

SUBMITTER: Han D 

PROVIDER: S-EPMC12105112 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature