Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses.

ABSTRACT:

Background

Venous thromboembolism (VTE) is a significant global health issue, yet effective therapeutic targets for its prevention and treatment remain elusive. This study aimed to identify plasma proteins causally associated with VTE risk using proteome-wide Mendelian randomization (MR) and colocalization analyses.

Methods

We utilized genome-wide association study (GWAS) data from the UK Biobank and FinnGen cohorts, encompassing 38,573 VTE cases and 946,373 controls. Plasma protein levels were quantified using Olink technology in the UK Biobank Pharma Proteomics Project (UKB-PPP) and SomaScan in the deCODE Health study. MR analysis was performed to assess causal relationships, followed by colocalization analysis to evaluate shared genetic variants. Functional enrichment ana

SUBMITTER: Li X 

PROVIDER: S-EPMC12105124 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature