The intrinsically disordered AB region: a key modulator of the molecular properties of human RXRγ.

ABSTRACT: The human retinoid X receptor γ (hRXRγ) is one of three characterized RXR subtypes, transcription factors belonging to the nuclear receptor superfamily. All RXR subtypes share nearly identical structural elements, including a conserved DNA-binding domain, a D region, a ligand-binding domain, and an F region. However, each subtype possesses a unique N-terminal AB region, which modulates the transcriptional activation of target genes in a cell- and promoter-dependent manner through its ligand-independent activation function involved in protein-protein interactions. Despite the functional significance of the AB region, its structural contributions, particularly in the context of the full-length receptor, remain largely unexplored. Here, we uncover the role of the AB region of hRXRγ in modulat

SUBMITTER: Soltys K 

PROVIDER: S-EPMC12105186 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature