Electroacupuncture exerts antipruritic and anti-inflammatory effects on atopic dermatitis by activating CB2 receptor.

ABSTRACT:

Background

The therapeutic benefits of electroacupuncture (EA) for atopic dermatitis (AD) are recognized, yet the underlying mechanisms remain elusive. Given the side effects associated with clinical CB2 receptor (CB2R) agonists used in AD treatment, our study seeks to elucidate EA's role in modulating CB2R in lesional skin and its impact on antipruritic and anti-inflammatory responses using an AD mouse model.

Methods

The AD model was induced with MC903, and EA was applied to'Qu chi'(LI11) and'He gu'(LI4) acupoints, corresponding to the neck dermatome. Mice were assessed for scratching behavior and scoring atopic dermatitis score every other day. Immunohistochemistry and immunofluorescence evaluated epidermal thickness, inflammatory cell infiltration, and CB2R expression. Me

SUBMITTER: Ge W 

PROVIDER: S-EPMC12105266 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature