Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies.

ABSTRACT:

Background

Imprinted genes are epigenetically regulated in normal tissues to follow monoallelic expression according to the parent of origin of each allele. Some of these patterns are dysregulated in cancer.

Results

We developed a novel computational multi-omic pipeline to evaluate monoallelic and biallelic expression patterns based on matched RNA-seq expression data, whole-exome sequencing information, and copy number data. We analyzed allelic expression of the entire genes, individual isoforms, and each exon of 59,283 autosomal protein-coding and ncRNA genes, with a focus on 94 genes previously reported to be imprinted. We analyzed 108 cell lines from 9 different tumor histologies using molecular data from the DepMap Portal for the Cancer Cell Line Encyclopedia. Allelic ex

SUBMITTER: Krushkal J 

PROVIDER: S-EPMC12105275 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature