Novel biomarkers for predicting successful liberation of renal replacement therapy for acute kidney injury: a systematic review.

ABSTRACT:

Introduction

Renal replacement therapy (RRT) is commonly used in critically ill patients with acute kidney injury (AKI). However, optimal timing of RRT liberation remains controversy. This meta-analysis evaluates novel biomarkers to predict successful RRT liberation in critically ill AKI patients.

Methods

The systematic review reported following PRISMA guidelines, PubMed, Embase, and Scopus were searched up to May 2, 2025, and were screened using predefined criteria. Methodological quality was assessed using the Newcastle-Ottawa scale. Pooled ROC-AUCs with 95% CIs were calculated; heterogeneity was evaluated using I² statistics.

Results

Sixteen studies (3020 patients) involving 23 biomarkers were included. Urinary neutrophil gelatinase-associated lipocalin

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12105276 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature