Multiparametric radiomics signature for predicting molecular genotypes in adult-type diffuse gliomas utilizing ¹⁸F-FET PET/MRI.

ABSTRACT:

Purpose

This study aimed to investigate the utility of radiomic features derived from multiparametric O-(2-¹⁸ F-fluoroethyl)-L-tyrosine (¹⁸F-FET) positron emission tomography (PET)/ magnetic resonance imaging (MRI) for the prediction of molecular genotypes in adult-type diffuse gliomas.

Methods

This retrospective study analyzed 97 adult-type diffuse glioma patients, divided into 70% training and 30% testing cohorts. Each participant underwent hybrid PET/MRI scans, including FLAIR, 3D T1-CE, apparent diffusion coefficient (ADC), and ¹⁸F-FET PET. After the multimodal images were spatially aligned, tumor segmentation was performed on the ¹⁸F-FET PET and then applied to other MRI sequences. A total of 994 radiomic features were extract

SUBMITTER: Bai J 

PROVIDER: S-EPMC12105308 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature