Effects of maternal isolated oligohydramnios on blood metabolic profile in term neonates: a retrospective observational study.

ABSTRACT:

Background

This study aimed to compare the blood metabolism status of newborns with maternal-isolated oligohydramnios (IO) and normal amniotic fluid and investigate the relationship between IO and fetal health.

Methods

Blood metabolites of 60 neonates with maternal IO and 60 healthy controls (HC) admitted to The Sixth Affiliated Hospital, Sun Yat-sen University (a discovery set), were analyzed using liquid chromatography-mass spectrometry to identify differential metabolites. Pathway analysis was performed to identify the most enriched metabolic pathways in discovery set. The discriminant metabolites were further verified in an independent set consisting of 50 neonates with maternal IO and 60 HC admitted to The Maternal and Child Health Care Hospital of Huadu.

Results

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12105382 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature