Combination of Cpb-Hsp70 typing methods reveals genetic divergence between Leishmania infantum strains causing human tegumentary leishmaniasis in northern Italy and central Spain: a retrospective study.

ABSTRACT:

Background

Tegumentary leishmaniasis (TL) caused by Leishmania infantum is an overlooked yet re-emerging disease endemic in Mediterranean Europe. Currently, no standardized molecular surveillance of circulating Leishmania strains is performed in European endemic areas, despite the potential public health implications of parasite biodiversity. This study aims to characterize parasite population haplogroups causing TL in two active endemic areas in southern Europe, i.e. Bologna (northern Italy) and Fuenlabrada (central Spain).

Methods

In this retrospective study, we typed 87 L. infantum samples from TL cases in the areas of Bologna and Fuenlabrada; these areas hosted the main European foci of human TL occurring in the last 15 years. Two Leishmania genomic typing targets were u

SUBMITTER: Gritti T 

PROVIDER: S-EPMC12105401 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature