Bidirectional Relationship Between Atopic Dermatitis and Psychiatric Comorbidities in Individuals of European Ancestry: A Mendelian Randomization Study.

ABSTRACT: Atopic dermatitis is a chronic inflammatory skin disorder that significantly impacts quality of life and is often associated with psychiatric comorbidities. How-ever, the causal relationship between atopic dermatitis and psychiatric disorders remains unclear. This study employed bidirectional 2-sample Mendelian randomization to investigate the potential causal relationships between atopic dermatitis and 8 psychiatric conditions: depression, anxiety, autism spectrum disorder, attention deficit hyperactivity disorder, suicidality, bipolar disorder, obsessive-compulsive disorder, and schizophrenia. Genetic instruments were derived from large-scale genome-wide association studies of European ancestry. Forward Mendelian randomization analysis indicated that atopic dermatitis causally increases

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12105540 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature