Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis.

ABSTRACT:

Introduction

The nuclear receptor TR4 binding protein, TRA16, has been implicated in lung carcinogenesis; however, its broader role across diverse human cancers remains poorly understood. Understanding TRA16's involvement in cancer biology could uncover novel regulatory mechanisms and potential therapeutic targets.

Methods

We conducted a comprehensive pan-cancer analysis of TRA16 expression and function across multiple human malignancies. Gene co-expression networks, pathway enrichment, transcription factor analysis, organoid modeling, and intercellular communication profiling were employed. Tumor mutation burden (TMB) and microenvironmental features were also assessed in relation to TRA16 expression, stratified by TP53 mutation status.

Results

Correlation analysis id

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12106028 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature