VLDL lipidomics reveals hepatocellular lipidome changes in metabolic dysfunction-associated steatotic liver disease.

ABSTRACT:

Background

The production of VLDL is one of the primary mechanisms through which liver cells regulate intracellular lipid homeostasis. We hypothesize that the disease characteristics of metabolic dysfunction-associated steatotic liver disease (MASLD) differentially impact VLDL lipid composition. This study comprehensively examines the relationship between VLDL-lipidome and MASLD histology and disease-associated genetics, aiming to define MASLD-related VLDL changes.

Methods

We performed untargeted lipidomics on serum VLDL particles in a cohort of biopsy-proven MASLD patients to examine the relationship between VLDL-lipidome and MASLD disease features as well as MASLD-related genetic variants.

Results

Among 1514 detected lipid species in VLDL, triglyceride (TG), phospha

SUBMITTER: Guardamino Ojeda D 

PROVIDER: S-EPMC12106201 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature