LncRNA SNHG15 promotes angiogenesis and improves cardiac repair after myocardial infarction through MiR-665-mediated KDR expression.

ABSTRACT: Angiogenesis is crucial for prolonging survival of the injured myocardium following myocardial infarction (MI). Long non-coding RNAs (lncRNAs), recognized as a novel class of regulatory RNAs, play significant roles in various biological processes. However, their role in cardiac angiogenesis is not well elucidated. This study aimed to identify angiogenic lncRNAs and investigate their roles and mechanisms following MI. In our study utilizing lncRNA sequencing within a mouse model of MI, systematic lncRNA profiling identified differentially expressed transcripts in the MI border zone at 7 days post-MI, with SNHG15 being notably upregulated in cardiac tissue and endothelial cells (ECs) of the peri-infarct area. Overexpression of SNHG15 in human coronary artery endothelial cells (HCAECs) led to

SUBMITTER: Liang X 

PROVIDER: S-EPMC12106210 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature