Concurrent evaluation of cerebral oxygen metabolism and upper airway architecture via temporally resolved MRI.

ABSTRACT: Obstructive sleep apnea (OSA) disrupts the oxygen supply during apneic and hypopneic events. To evaluate the feasibility of concurrently monitoring cerebral metabolic rate of oxygen (CMRO₂) and airway anatomy, a magnetic resonance imaging (MRI) pulse sequence was developed that interleaves measurements of CMRO₂ with anatomic imaging of the upper airway at a temporal resolution of 5 seconds. The sequence was first tested in healthy subjects during wakefulness to detect the effect of volitional breath-hold and swallowing apneas on neuro-metabolic parameters and airway morphology. Subsequently, select patients with diagnosed OSA and healthy reference subjects were scanned during 90 minutes of wakefulness and sleep with concurrent electroencephalographic (EEG) monitoring

SUBMITTER: Dennison JB 

PROVIDER: S-EPMC12106373 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature